• Trial(s) for Heart and Vascular Center

    Study Objective Contact
    Cardiovascular Inflammation Reduction Trial (CIRT): A Randomized, Double-Blind, Placebo-Controlled, Event-Driven Trial of Weekly Low-Dose Methotrexate (LDM) in the Prevention of Recurrent Cardiovascular Events Among Stable Coronary Artery Disease Patients with Type 2 Diabetes or Metabolic Syndrome [LCID Study Number: 2013-070] Researchers are seeking to determine if methotrexate reduces heart attacks, strokes, or death in people with type 2 diabetes or metabolic syndrome who have already had at least one heart attack or have major blockages in more than one coronary artery found on a heart catheterization. Principal Investigator(s):
    Timothy S. Draper, Jr., DO

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Judy E. Pendleton,
    Michele Rybicki, RN.
    CELESTIAL Post Approval Registry (Corox OTW, Endocardial, Left VEntricular STeroId, LeAd, BipoLar Post Approval Registry) [LCID Study Number: 2009-060] The purpose of this Registry study is to confirm the long term safety and effectiveness of the Corox OTW (-S) BP LV Lead, a non-investigational lead. In this Registry, data will be collected on the leads that connect the CRT system to the ventricles. These leads are legally marketed in the United States and not investigational products. The U.S. Federal Drug Administration (FDA) is requiring the company, BIOTRONIK, to collect additional long term data on these leads. The study involves collection and analysis (testing) of data at regular follow-up visits with your doctor. These follow up visits with your doctor are no different than would otherwise occur if you did not enroll in this study. Principal Investigator(s):
    Jonathan S. Silver, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Jean M. Byrne, RN.
    Circulating Tumor Cells in Patients with Primary Carcinoma of the Lung and Patients who are Candidates for Pulmonary Metastasectomy for Metastatic Colorectal, Breast, and Prostate Cancer [LCID Study Number: 2011-076] Why is this study being done? To determine if tumor cells can be isolated and treated from peripheral blood and blood from the part of lung that is being removed for the treatment of the tumor. Principal Investigator(s):
    Christina Williamson, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Deborah J. Gannon,
    Frances A. Babcock.
    Comparison of Physiologic Response with Rate Adaptive Pacing Driven by Minute Ventilation and Accelerometer [LCID Study Number: 2014-005] The purpose of this study is to determine which pacemaker response sensor is best (motion driven or breathing driven). The study is also investigating whether optimizing the sensor based on the individual patient will give better results in terms of increasing the patient's exercise capacity. Patients with or planning to receive a Boston Scientific pacemaker may be eligible to participate. Principal Investigator(s):
    G. Muqtada Chaudhry, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Jean M. Byrne, RN.
    CONVERGE: Convergence of Epicardial and Endocardial RF Ablation for the Treatment of Symptomatic Persistent AF [LCID Study Number: 2014-049] The objective of this study is to determine whether the Convergent procedure, a combination of ablation on the outside and inside of the heart, is superior to traditional catheter ablation (inside the heart only) for patients with persistent atrial fibrillation. Principal Investigator(s):
    Bruce G. Hook, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Jean M. Byrne, RN.
    Global Anticoagulant Registry in the FIELD Observing Treatment and Outcomes in Patients with Treated Acute Venous Thromboembolic Events in the Real World - GARFIELD-VTE [LCID Study Number: 2014-040] The purpose of this observational registry study is to learn more about immediate and long-term treatment and results in patients with blood clots to determine best practices in the future. Principal Investigator(s):
    Michael S. Levy, MD, MPH

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Judy E. Pendleton.
    Randomized, Double-Blind, Placebo Controlled Study of the Short Term Clinical Effects of Tolvaptan in Patients Hospitalized for Worsening Heart Failure with Challenging Volume Management [LCID Study Number: 2014-074] The purpose of this study is to test the effectiveness, safety and side effects of an investigational drug called tolvaptan for patients with Congestive Heart Failure (CHF). Tolvaptan is used to increase low levels of sodium in the blood in people who have heart failure. Principal Investigator(s):
    Richard D. Patten, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Jean M. Byrne, RN,
    Michele Rybicki, RN.
    Ranolazine ICD Trial (RAID) Late Sodium Current Blockade in High-Risk ICD Patients [LCID Study Number: 2011-032] The purpose of the study is to see how effective and safe a drug called ranolazine is in reducing the risk of fast cardiac arrhythmias and death in people with implantable cardioverter defibrillators (ICDs). Principal Investigator(s):
    Jonathan S. Silver, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Jean M. Byrne, RN.
    Renal Denervation in Patients with Uncontrolled Hypertension -SYMPLICITY HTN-3 [LCID Study Number: 2011-080] The purpose of this study is to provide additional information about a medical device intended to help treat high blood pressure in patients whose blood pressure is not controlled, despite treatment with multiple blood pressure medications. You are being considered for participation in this study because your blood pressure Principal Investigator(s):
    Sergio Waxman, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Jean M. Byrne, RN,
    Judy E. Pendleton,
    Michele Rybicki, RN.
    The Leadless II Study: A Safety and Effectiveness Trial for a Leadless Pacemaker System [LCID Study Number: 2014-013] The purpose of this study is to evaluate the safety and effectiveness of a leadless pacemaker system in treating patients with slow heart rate or irregular heartbeats. The leadless pacemaker is implanted through a vein in the leg into the heart and is intended to help reduce certain complications associated with traditional pacemakers because it does not require a pocket under the collar bone and it does not have lead wires. This pacemaker is not approved by the Food and Drug Administration (FDA) and hence is considered investigational. Principal Investigator(s):
    Bruce G. Hook, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Jean M. Byrne, RN.
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