Title: Deep Brain Stimulation Surgery in the Subthalamic Nucleus for Parkinson’s Disease Using Low Frequency Stimulation
Study Identifier: LCID: 2010-083, DBS study
Principal Investigator: Diana Apetauerova, MD
Sponsor: Lahey Hospital & Medical Center, Robert E. Wise
Purpose: The purpose of this study is to study the effectiveness of low frequency deep brain stimulation (DBS) or a combination of high/low frequency stimulation in patients with Parkinson’s disease (PD) who experience significant gait problems.
Summary: DBS is a very effective treatment of PD in later stages with long term beneficial effects on motor symptoms, including bradykinesia (slowness), rigidity, tremor, and dyskinesia (involuntary movement). Patients are typically programmed with high frequency stimulation (>100 hz) to manage these symptoms. While high frequency DBS is generally effective for motor symptoms, gait and balance problems can worsen after surgery. Not much is known about whether low frequency stimulation (>100 hz) or a combination of both high and low frequency stimulation may be better than high frequency stimulation alone at treating gait and balance problems. Approximately 20 patients will participate in this study at the Lahey Hospital & Medical Center.
Study Type: Interventional
Length/Duration: 1 Month/ 3 visits to clinic (screening, week 2 and week 4)
ELIGIBILITY: If you are interested in this study and want to see if you may qualify for this study, click here, to complete a brief eligibility form.
Contact: For more information on this study, please contact the study coordinator at Nicholas.F.Ventura@Lahey.org or (781) 744-3216.
Title: Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with PD
Study Identifier: LCID: 2012-070, DaTscan study
Purpose: The effectiveness of DaTscan™ for monitoring disease progression or response to therapy, such as DBS, has not yet been established. We want to look at this dopamine activity with DaTscan before and after your DBS surgery to see if, what, changes occur in the brain.
Summary: This study is looking at patients diagnosed with Parkinson’s disease (PD) who plan to undergo Deep Brain Stimulation (DBS) surgery. Deep brain stimulation (DBS) surgery is an established treatment option for Parkinsons disease (PD) that directly changes brain activity with reversible effects. The mechanism or underlying principles by which DBS surgery benefits patients with PD, however, remains unclear. PD is caused by loss of dopamine-secreting neurons (nerve cells) in the part of the brain that affects movement. Medications used to treat the symptoms of PD are generally those that are targeted to replace this dopamine loss. DaTscan™ (Ioflupane I 123 Injection) in brain SPECT imaging (a type of imaging test that views how blood flows through arteries and veins in the brain) is an FDA approved screening test which helps differentiate between PD and other similar movement disorders and it permits us to measure and see dopamine’s activity in the brain. Approximately 20 patients will participate in this study at the Lahey Hospital & Medical Center.
Study Type: Observational Investigator Initiated Pilot
Length/Duration: The total time for your study participation is 7 months. You will be evaluated up to 1 month prior to your DBS surgery and followed for up to 6 months after your DBS surgery.
Contact: For more information on this study, please contact the study coordinator at Nicholas.F.Ventura@lahey.org or (781) 744-3216.