The Department of Neurology at Lahey Hospital & Medical Center supports and participates in various original research efforts. These efforts include investigator-initiated drug or device trials, observational studies, questionnaire studies, outcome studies, case reports and retrospective reviews. The results of these original projects are often published in peer reviewed journals.
McMillan HJ, Kang PB, Jones HR, Darras BT. "Childhood chronic inflammatory demyelinating polyradiculoneuropathy: Combined analysis of a large cohort and eleven published series". Neuromuscul Disord. 2013 Feb;23(2):103-11
Karakis I, Jones HR, Gajjar AA, Baharozian DB, Srinivasan J. "Teaching NeuroImages: Gelsolin-related amyloidosis: A rare cause of progressive facial diparesis". Neurology. 2013 Feb 26;80(9):e94.
To see a listing of neurology publications by Lahey neurology staff in previous years, click below:
Complete articles or abstracts may be available at http://www.ncbi.nlm.nih.gov/pubmed/
Physicians from the Department of Neurology also regularly present preliminary or final results of their original research in the format of poster presentations at peer reviewed neurological meetings often hosted by international professional associations or organizations, including the highly regarded annual meetings of the American Academy of Neurology and American Neurological Association.
Recent Poster Presentations:
To preview recent posters, click on one of the poster titles below.
The 65th Annual Meeting of the American Academy of Neurology (AAN)
The 136th Meeting of the American Neurological Association (ANA)
The Annual Meeting of the Consortium of Multiple Sclerosis Centers (CMSC)
The 26th Annual Meeting of the Associated Professional Sleep Societies (APSS)
The 16th International Congress of Parkinson's Disease and Movement Disorders
The 64th Annual Meeting of the American Academy of Neurology (AAN)
The 50th Annual Meeting of the American Society of Neuroradiology (ASNR) & The Foundation of the ASNR Symposium
The 40th Annual Meeting of the International Neuropsychological Society
Clinical drug and device trials sponsored by pharamceutical and biotechnology companies are regularly conducted in the department of neurology at Lahey Hospital & Medical Center. Once the results of these trials are finalized they are published in peer reviewed journals, and results may also be found on www.clinicaltrials.gov.
Results of the NINDS and Mt. Sinai School of Medicine sponsored CombiRx clinical trial, “A Multicenter Double-Blind Randomized Study Comparing the Combined Use of Interferon Beta-1a and Glatiramer Acetate to Either Agent Alone in Patients with RRMS”, were published in the February 2013 journal of Annals of Neurology (Lublin FD, Cofield SS, Cutter GR, Conwit R, Narayana PA, Nelson F, Salter AR, Gustafson T, Wolinsky JS; for the CombiRx Investigators. Randomized study combining interferon & glatiramer acetate in multiple sclerosis. Ann Neurol. 2013 Feb 19.)
Results of the Allon Therapeutics, Inc. sponsored clinical trial, "A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Safety and Efficacy of Davunetide for the Treatment of Progressive Supranuclear Palsy", were announced on December 18, 2012.
Results of the Biogen Idec sponsored clinical trial, “A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Dose-Comparison Study To Determine The Efficacy And Safety Of BG00012 In Subjects With Relapsing-Remitting Multiple Sclerosis”, were published in the September 2012 issue of the New England Journal of Medicine. (Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Tornatore C, Sweetser MT, Yang M, Sheikh SI, Dawson KT; DEFINE Study Investigators. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med. 2012 Sep 20;367(12):1098-107.)
Preliminary results of the NINDS sponsored clinical trial, "Clinical Trial of Ceftriaxone in Subjects with ALS", were announced in August 2012.
Results of the NIH sponsored clinical trial, “Warfarin vs. Aspirin in Reduced Cardiac Ejection Fraction (WARCEF)” were presented at the 2012 International Stroke Conference on February 3, 2012.
Results of the ANS and St. Jude sponsored clinical trial, “A Clinical Evaluation of bilateral stimulation of the subthalamic nucleus (STN) using the ANS Totally Implantable Deep Brain Stimulation System as an adjunctive treatment for reducing some of the symptoms of advanced, levodopa-responsive Parkinson’s disease that are not adequately controlled with medication” were published in the February 2012 journal of Lancet Neurol. ( Okun MS, Gallo BV, Mandybur G, Jagid J, Foote KD, Revilla FJ, Alterman R, Jankovic J, Simpson R, Junn F, Verhagen L, Arle JE, Ford B, Goodman RR, Stewart RM, Horn S, Baltuch GH, Kopell BH, Marshall F, Peichel D, Pahwa R, Lyons KE, Tröster AI, Vitek JL, Tagliati M; SJM DBS Study Group. Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trial. Lancet Neurol. 2012 Feb;11(2):140-9)
Results of the Alzheimer's Disease Cooperative Study (ADCS), National Institute on Aging and the University of California San Diego sponsored clinical trial, “A Randomized, Double-Blind, Placebo-Controlled Trial of Valproate to Attenuate the Progression of Alzheimer's Disease (AD)” were published in the September 2011 journal of Neurology and the August 2011 journal of Arch Gen Psychiatry.
RESEARCH IN NEUROLOGY
The American Heart Association/American Stroke Association's Get With The Guidelines program has again awarded Lahey Clinic’s stroke service the Stroke Gold Performance Achievement Award.