• Trial(s) for Pulmonary and Critical Care Medicine

    Study Objective Contact
    A Prospective Parallel Controlled Pilot Study on the Readmission Rate of Chronic Obstructive Pulmonary Disease [LCID Study Number: 2014-041] This is a prospective, observational, parallel controlled pilot study. The Pulmonary Department developed a new Transitional Care Management (TMC) protocol for COPD patients to reduce COPD readmission rate. This study will test whether the new management protocol will reduce the COPD readmission rate. The study will be implemented on the 6SE and 7SE floors of the hospital. Principal Investigator(s):
    Timothy N. Liesching, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Yuxiu Lei, PhD.
    A Prospective Post-Approval Study with the Spiration (IBV) Valve System for the Treatment of Prolonged Air Leak [LCID Study Number: 2012-003] The purpose of the study is to collect additional information about the safety and potential benefit of using the Spiration (IBV) Valve System to treat prolonged or serious air leaks of the lung. The Spiration (IBV) Valve System is a Humanitarian Use Device (HUD) approved by the U.S. Food and Drug Administration (FDA) to treat serious or prolonged air leaks of the lung following lobectomy, segmentectomy, or lung volume reduction surgery Principal Investigator(s):
    Ghazwan Acash, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Deborah J. Gannon.
    Early Goal Directed Diuresis: Avoiding Over-Resuscitation in Septic Patients Utilizing Arterial Pulse Pressure Variation Monitoring [LCID Study Number: 2012-068] The purpose of this study is to test whether “Flo-Trac” is better in guiding appropriate removal of fluid during septic shock as compared to current standard of care. Principal Investigator(s):
    Thomas D. Wold, DO

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Yuxiu Lei, PhD.
    EMPROVE (Evaluation of the SVS Valve for EMphysema to ImPROVE Lung Function) Spiration® Valve System Study: A Prospective Randomized, Controlled Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the Spiration® Valve System (SVS) for the Single-Lobe Treatment of Severe Emphysema [LCID Study Number: 2013-030] The objective of this study is to evaluate the safety and effectiveness of the IBV Valve System for the treatment of severe emphysema. The IBV valve is an investigational device. It is a small, umbrella-shaped, one-way valve that is placed inside the airways of diseased parts of lungs and redirects the air to healthier parts of the lung. Eligible subjects will be randomized in a 2:1 ratio to treatment with either the IBV Valve System or continued optimal medical managment (control arm). Study subjects will be followed over a period of 6 months. Principal Investigator(s):
    Carla R. Lamb, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Joyce E. Pelletier,
    Maria Wertz.
    Post -FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma [LCID Study Number: 2011-063] The purpose of this study is to test the effectiveness, safety and side effects of bronchial thermoplasty (which is performed with the Alair System) for patients with severe persistent asthma. Bronchial thermoplasty is a procedure that applies mild heat to the airway wall that is designed to reduce the amount of airway smooth muscle. The procedure reduces the ability of the airway walls to contract and narrow during an asthma attack. Principal Investigator(s):
    Carla R. Lamb, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Donna R. Spencer,
    Joyce E. Pelletier.
    Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the Setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) [LCID Study Number: 2014-065] The purpose of the research study is to determine why some people who smoke develop lung cancer while others do not. The project will look at how smoking affects the genetic building blocks (RNA and DNA) and protein within cells lining the airways of your lung, mouth, and nose. We will also see if similar changes can be found in cells from your blood. Principal Investigator(s):
    Carla R. Lamb, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Kathryn B. Salnikov,
    Travis B. Sullivan, MS.
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  • An introduction from Dr. Andrew Villanueva