• Trial(s) for Pulmonary and Critical Care Medicine

    Study Objective Contact
    A Multicenter, Double-Blind, Randomized, Comparative Study of the Safety, Tolerability, Efficacy, and Pharmacokinetics of CF-301 vs. Placebo in Addition to Standard-of-Care Antibacterial Therapy for the Treatment of Adult Patients with Staphylococcus aureus Bloodstream Infections (Bacteremia) Including Endocarditis [LCID Study Number: 2017-004] The purpose of this Study is to test the effectiveness, safety and side effects of the study drug, CF-301, for patients with the bacteria Staphylococcus aureus (S. aureus) in their blood. Principal Investigator(s):
    Timothy N. Liesching, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Yuxiu Lei, PhD.
    A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, COMPARATOR-CONTROLLED STUDY TO EVALUATE THE SAFETY AND EFFICACY OF INTRAVENOUS TO ORAL DELAFLOXACIN IN ADULT SUBJECTS WITH COMMUNITY-ACQUIRED BACTERIAL PNEUMONIA [LCID Study Number: 2017-025] Delafloxacin is an investigational drug. The purpose of this study is to determine if delafloxacin (an antibiotic) is safe and effective in the treatment of community-acquired pneumonia compared with another antibiotic, moxifloxacin. Principal Investigator(s):
    James M. Dargin, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Yuxiu Lei, PhD.
    An Observational Pilot Study of the Aedio Cardio-Respiratory Monitoring System in Comparison to Pulmonary Function Testing [LCID Study Number: 2017-051] The purpose of this study is to determine if breath recordings from the Aedio Digital Monitoring Device (DMD) can mirror changes in your breathing as measured by pulmonary function test (PFT). The PFT is the “gold standard” to measure your lung function that your physician routinely orders to keep track of your condition. If the DMD can mirror these PFT changes, then the DMD could be developed as an at-home device for patients to self-monitor their asthma status. Principal Investigator(s):
    Timothy N. Liesching, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Yuxiu Lei, PhD.
    EMPROVE (Evaluation of the SVS Valve for EMphysema to ImPROVE Lung Function) Spiration® Valve System Study: A Prospective Randomized, Controlled Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the Spiration® Valve System (SVS) for the Single-Lobe Treatment of Severe Emphysema [LCID Study Number: 2013-030] The objective of this study is to evaluate the safety and effectiveness of the IBV Valve System for the treatment of severe emphysema. The IBV valve is an investigational device. It is a small, umbrella-shaped, one-way valve that is placed inside the airways of diseased parts of lungs and redirects the air to healthier parts of the lung. Eligible subjects will be randomized in a 2:1 ratio to treatment with either the IBV Valve System or continued optimal medical managment (control arm). Study subjects will be followed over a period of 6 months. Principal Investigator(s):
    Carla R. Lamb, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Joyce E. Pelletier.
    Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry [LCID Study Number: 2016-063] The purpose of the IPF-PRO registry is to collect data and biological samples from patients who have been diagnosed with pulmonary fibrosis to be stored and used for supporting future research studies. Principal Investigator(s):
    Timothy N. Liesching, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Yuxiu Lei, PhD.
    Post -FDA Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma [LCID Study Number: 2011-063] The purpose of this study is to test the effectiveness, safety and side effects of bronchial thermoplasty (which is performed with the Alair System) for patients with severe persistent asthma. Bronchial thermoplasty is a procedure that applies mild heat to the airway wall that is designed to reduce the amount of airway smooth muscle. The procedure reduces the ability of the airway walls to contract and narrow during an asthma attack. Principal Investigator(s):
    Carla R. Lamb, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Joyce E. Pelletier.
    Prospective Registry to Evaluate Percepta Bronchial Genomic Classifier Patient Data: The PERCEPTA Registry [LCID Study Number: 2015-064] The purpose of this registry is to collect data about the clinical use of the Percepta test. Percepta is a new, commercially available test that uses genomic analysis of cells that line the airway to identify patients at low risk for lung cancer following bronchoscopies where no malignancy is found. It reduces ambiguity and informs on which patients may be considered for CT surveillance in lieu of invasive procedures. Principal Investigator(s):
    Carla R. Lamb, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Katherine A. Wasilewsky,
    Naysha Rodriguez.
    Safety and Effectiveness of the Spiration Valve System in Air Leaks VAST (Valves Against Standard Therapy) [LCID Study Number: 2016-050] The objective of this study is to determine the safety and effectiveness of an investigational (not approved by the FDA) device called the Spiration Valve System in patients who have an air leak in their lungs. One of more of these valves would be placed in the patients' airways. The valves are made to limit the amount of air that can reach the damaged part of the lungs. Principal Investigator(s):
    Carla R. Lamb, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Joyce E. Pelletier.
    Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the Setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) [LCID Study Number: 2014-065] The purpose of the research study is to determine why some people who smoke develop lung cancer while others do not. The project will look at how smoking affects the genetic building blocks (RNA and DNA) and protein within cells lining the airways of your lung, mouth, and nose. We will also see if similar changes can be found in cells from your blood. Principal Investigator(s):
    Carla R. Lamb, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Katherine A. Wasilewsky,
    Naysha Rodriguez,
    Travis B. Sullivan, MS.
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