• Clinical Trials - Ovarian Cancer

    Study Objective Contact
    A Phase 3 Randomized Double-Blind Trial of Maintenance with Niraparib versus Placebo in Patients with Platinum Sensitive Ovarian Cancer [LCID Study Number: 2014-024] NOVA is a maintenance trial for women with ovarian cancer, aged 18 and older, to find out if niraparib (a PARP inhibitor) can help delay worsening of ovarian cancer among patients who had a good response to previous treatment with a platinum-type chemotherapy drug (i.e. cisplatin, carboplatin). Niraparib will be compared to placebo and patients will be randomized so that 2 out of 3 patients will take niraparib and 1 out of 3 will take placebo. This study is designed with the hope of preventing worsening of the cancer after another treatment has caused the cancer to improve. Principal Investigator(s):
    Corrine Zarwan, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Joyce E. Pelletier.
    A Pilot Study: Acupuncture Integrative Care for Ovarian Cancer Patients [LCID Study Number: 2012-046] A Pilot study of Acupuncture Integrative Care for Ovarian Cancer Patients: This study is to learn about the potential benefits of acupuncture treatment for ovarian cancer patients. Principal Investigator(s):
    Jonathan B. Ammen

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Amanda M. Pietras.
    GOG 0273: Chemotherapy Toxicity in Elderly Women with Ovarian, Primary Peritoneal or Fallopian Tube Cancer [LCID Study Number: 2012-028] The major goal of this study is to see if physicians can predict how women will tolerate and complete chemotherapy as prescribed using simple assessments looking at your ability to do activities of daily living. Another goal of the study is to look at how chemotherapy works in older women with cancer. Principal Investigator(s):
    Corrine Zarwan, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Joyce E. Pelletier.
    Molecular Analysis of Cancer [LCID Study Number: 2011-048] The purpose of this research is to discover molecular changes involved in cancer. We hope that a better understanding of these changes can improve cancer management. This research may include genetic and/or genomic analysis (tests to determine and compare your genetic sequence, or DNA). Some of the tissue we collect for our research may be submitted to the National Cancer Institute Cancer Genome Atlas Project. The goal of this project is to determine the genomic changes involved in more than 20 types of human cancer. Principal Investigator(s):
    Kimberly R. Christ, PhD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Doreen L. Browne, ,CCRP,
    Jane S. Nalwalk,
    Linda M. Topjian.
    Validation of Biomarkers For Detection of Ovarian Cancer [LCID Study Number: 2010-074] Validation of Biomarkers for Detection of Ovarian Cancer: In collaboration with Tufts Medical Center, this study is to generate and then validate a marker panel that can be used to screen for invasive ovarian malignancy. Principal Investigator(s):
    Corrine Zarwan, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Kori D. Hesse.