• Clinical Trials - Urothelial Cancer

    Study Objective Contact
    A Phase I, Open-Label, Multiple-Ascending Dose Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of Avelumab (MSB0010718C) in Subjects with Metastatic or Locally Advanced Solid Tumors and Expansion to Selected Indications. [LCID Study Number: 2013-051] A Phase I, open-label, multiple-ascending dose trial to investigate the safety, tolerability, pharmacokinetics, biological and clinical activity of MSB0010718C in subjects with metastatic or locally advanced solid tumors and expansion to selected indications. Principal Investigator(s):
    Corrine Zarwan, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Julie Roache.
    A Phase II Trial Of NeoAdjuvant Dose-Dense MVAC With Neulasta (Pegfilgrastim) Support In Subjects With Muscle-Invasive Urothelial Carcinoma [LCID Study Number: 2009-056] The purpose of this study is to test the effectiveness, safety and side effects of MVAC chemotherapy (methotrexate, vinblastin, adriamycin, cisplatin) with hematologic growth factor support (Neulasta support) for patients with muscle-invasive bladder cancer prior to surgery. THIS STUDY IS NO LONGER ACCEPTING NEW PATIENTS. Principal Investigator(s):
    Jacob M. Sands, MD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Sherry G. Heldt, RN.
    Molecular Analysis of Cancer [LCID Study Number: 2011-048] The purpose of this research is to discover molecular changes involved in cancer. We hope that a better understanding of these changes can improve cancer management. This research may include genetic and/or genomic analysis (tests to determine and compare your genetic sequence, or DNA). Some of the tissue we collect for our research may be submitted to the National Cancer Institute Cancer Genome Atlas Project. The goal of this project is to determine the genomic changes involved in more than 20 types of human cancer. Principal Investigator(s):
    Kimberly R. Christ, PhD

    For more information about this Research Study call 781-744-8027.

    Study Coordinator(s):
    Doreen L. Browne, ,CCRP,
    Jane S. Nalwalk,
    Linda M. Topjian.