A Unique Collaboration amongst Experts for Leading-Edge Research
Lahey Clinic offers a truly unique collaboration between researchers and clinicians in the field of urology. The Cell and Molecular Biology Laboratory is an integral part of the Institute of Urology, with first year urology residents spending a full year in the laboratory, obtaining basic science and clinical research experience under the guidance of well-established and talented researchers.
Through this distinctive opportunity, residents become acquainted with the scientific method and translational research laboratory techniques and are introduced to the methodologies of medical research. The research experience is designed to provide the complete technical and supervisory support needed to instill in residents the basic principles of study design, hypothesis formulation, investigative methodology and manuscript preparation.
Residents are charged with completing research projects involving cutting-edge experimental approaches that culminate in publications and presentations, nationally and internationally. Through the experience gained, residents become the perfect liaisons between the urology clinic and laboratory, facilitating the clinician/scientist interactions critical to advancing medicine.
Urology residents and researchers in the Cell and Molecular Biology Laboratory are currently highly involved in the generation of proteomic approaches for the analysis of human tissues, with the goal of providing clinicians with new tools to aid in patient management. Our researchers believe this approach will be important as we move toward personalized medicine.
Ongoing Clinical Studies
Listed below are clinical research studies currently underway in Lahey Clinic's Institute of Urology. To obtain additional information on any of these studies or to refer a patient, please contact
Linda Topjian
Programs Manager
Lahey Clinic
Department of Urology - 4SE
41 Mall Road
Burlington, MA 01805
Phone: 781-744-8711
Fax: 781-744-5635
E-mail: Linda.M.Topjian@lahey.org
Bladder Cancer
- Molecular Analysis of Bladder Cancer - Molecular analysis for purposes of diagnostic, prognostic and therapeutic advancements. John A. Libertino, MD - Principal Investigator
- Evaluation of Non-Invasive Assays - To aid in the diagnosis, prognosis and selection of agents for use in targeted therapy. John A. Libertino, MD - Principal Investigator
Prostate Cancer
- Identification of Aberrant Gene Expression in Human Prostatic Carcinoma - Molecular and proteomic approaches to identify events underlying tumor progression to aid in clinical decision making processes. John A. Libertino, MD - Principal Investigator
- AMS Anastomosis Device - Facilitating the vesico-urethral anastomosis following radical prostatectomy. John A. Libertino, MD, and Ingolf Tuerk, MD, PhD - Co-Investigators
- Study of Urethral Sphincter Utilizing EMG - Assessing the internal urethral sphincter with electromyography during radical prostatectomy. John A. Libertino, MD, and John T. Stoffel, MD - Co-Investigators
- Transcutaneous Electrical Stimulation (TENS) During TRUS Biopsy - Testing the effectiveness of transcutaneous electrical stimulation (TENS) in reducing pain associated with TRUS biopsy. John T. Stoffel, MD - Prinicipal Investigator
Kidney Cancer
- ARISER/Rencarex® - Monoclonal antibody study for non-metastatic, post nephrectomy patients at high risk for recurrence. John A. Libertino, MD - Principal Investigator. Open to outside patient referral.
Incontinence
- ACT (Adjustable Continence Therapy) - Device study using a periurethral prosthetic system for treatment of female stress urinary incontinence. John Bressette, MD - Principal Investigator. Closed to accrual.
- Vesicare vs. Vesicare and Behavior Modification for Treatment of Overactive Bladder - Comparing behavioral modification and Vesicare to Vesicare alone for the treatment of urge incontinence in patients with overactive bladder. John T. Stoffel, MD - Prinicipal Investigator. Open to outside patient referral.
Reconstructive Urology
- Management of the Failed Urolume with Simplification of Explantation and Urethral Reconstruction. Leonard Zinman, MD; John Stoffel, MD; Jill Buckley, MD
- Intralesional and Systemic Adjunct in the Endoscopic Management of Post Radical Prostatectomy Bladder Neck Anastomotic Stricture and Separation Injury. Leonard Zinman, MD, and Jill Buckley, MD - Co-Investigators
- Management of Radiation Injured Rectourethral Fistulas with Preservation of Urinary and Rectal Function. Leonard Zinman, MD
