• Protease Inhibitors

     

    Generic 

    Brand 

    Dose* (total milligrams) 

    Side Effects & Comments 

    Saquinavir
    hard gel cap 
    Invirase 3 pills (600mg) every 8h Take with fatty food
    Blue & yellow capsule 
    Not absorbed unless with Norvir. Store in tight container at room temperature.
    Saquinavir
    soft gel cap 
    Fortovase 6 pills (1200mg) every 8h
    Take with fatty food
    Beige capsule 
    Newer & better than Invirase. Store bottle in fridge.
    Some drug interactions.
    Ritonavir  Norvir 6 pills (600mg) or 1 ½ tsps every 12h
    Take with fatty food
    White capsule or liquid 
    Nausea, Diarrhea, Neuropathy Gets better after 2-4 wks.
    Many drug interaction.
    Store capsules in fridge. Ritonavir liquid is 40% alcohol.
    Indinavir  Crixivan 2 pills (800mg) every 8h Take on empty stomach or with nonfat meal
    White capsule 
    Nausea
    Kidney stones 6-8%
    Drink 6-8 glasses of water/juice a day.
    Store in original container in dry place at room temperature.
    Some drug interactions.
    Nelfinavir  Viracept 3 pills (750mg) every 8h or 5 pills (1250mg) every 12h
    Blue tablet 
    Nausea, diarrhea
    Some drug interactions
    Amprenavir  Agenerase 24 capsules (1200 mg) or 6 Tbl every 12h; when given with ritonavir - 1200 mg plus 200 mg ritonavir or 600 mg with 100 mg ritonavir every 12h
    Avoid fatty food
    Beige capsule or liquid 
    Nausea, diarrhea, rash, Neuropathy
    Some drug interactions
    Contains vitamin E
    Avoid if allergic to sulfonamide
    Avoid liquid if also taking disulfiram or metronidazole
    Fosamprenavir  Lexiva 2 tablets (1400 mg) every 12h, 2 tablets plus 200 mg ritonavir once daily, or 1 tablet (700 mg) plus ritonavir 100 mg every 12h; treatment-experienced: 1 tablet (700 mg) plus ritonavir 100 mg every 12h
    White tablet
    No food restrictions
    Rash, depression, diarrhea, nausea, neuropathy, stomach ache, fatigue
    Some drug interactions
    Lopinivir-ritonavir  Kaletra 3 pills every 12h
    Take with food
    Orange capsule 
    Nausea, diarrhea, rash, neuropathy
    Some drug interactions
    Atazanavir  Reyataz 2 capsules (200 mg) once daily; 300 mg (one 300 mg or two 150 mg) capsules plus ritonavir 100 mg once daily in treatment-experienced patients
    Take with food
    Blue capsule 
    Rash, abdominal pain, diarrhea, nausea, headache, asymptomatic jaundice, neuropathy, rarely can cause arrhythmias
    Some drug interactions
    Tipranavir  Aptivus 2 capsules (500 mg) every 12h plus ritonavir 200 mg every 12 h
    Take with food
    Brown capsule 
    Diarrhea, nausea, vomiting, fatigue, increased cholesterol; may cause liver problems
    Avoid if sulfa allergy
    Some drug interactions
    Darunavir  Prezista 2 tablets (600 mg) plus ritonavir 100 mg every 12h
    Take with food
    Orange oval tablet 
    Diarrhea, nausea, headache, runny nose or sore throat; may cause elevated liver functions or cholesterol

    *Doses may change based on weight, kidney or liver function, or other medicines 

    For additional information on any of the above medications, please visit the NIH AIDS Drug database and the Test Positive Aware Network's HIV Drug Guide for pictures of each drug.

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