• Tardive Dyskinesia Trials

    Title: Low-frequency repetitive transcranial magnetic stimulation in patients with medication-refractory tardive dyskinesia 

    Study Identifier:  LCID: 2007-108, rTMS study

    Principal Investigator: Julie Leegwater-Kim, MD, PhD 

    Sponsor: Lahey Hospital & Medical Center, Robert E. Wise

    Purpose:  The purpose of this study is to determine the safety, side effects and effectiveness of repetitive transcranial magnetic stimulation (rTMS) in tardive dyskinesia (TD). The effectiveness of rTMS will be tested by comparing it to the effects of sham rTMS (a procedure that mimics actual rTMS but does not deliver treatment). 

    Summary:  Currently there is no cure or standard treatment for TD. Transcranial magnetic stimulation is an investigational, non-invasive, neurophysiologic procedure that allows the induction of a current in the brain using a magnetic field to pass the scalp and the skull safely and painlessly to stimulate and alter brain activity. Repetitive TMS (rTMS), in which a train of magnetic impulses is delivered in a short period of time, i.e. milliseconds to several seconds, may be capable of changing brain activity for a period of minutes, hours, days or weeks when it is applied repeatedly several days in a row.

    rTMS has been studied in other neurological disorders including Parkinson’s disease, Huntington’s disease and dystonia (abnormal involuntary movements that can result in twisting or abnormal postures) as well as in psychiatric diseases such as depression. In studies of other movement disorders, rTMS has been found to have a beneficial effect in reducing abnormal movements. As TD is a movement disorder with many similarities to these other disorders, doctors think that rTMS might help in the treatment of TD. Participation in this study consists of 3 parts: a baseline screening visit and 2 treatment phases (weeks 1-6).  All subjects will participate in each phase. 

    Study Type: Interventional

    Length/Duration: Total duration of the study is six weeks and will consist of 24 visits

    ELIGIBILITY: If you are interested in this study and want to see if you may qualify for this study, click here, to complete a brief eligibility form.  

    Contact: For more information on this study, please contact the study coordinator at Nicholas.F.Ventura@Lahey.org or (781) 744-3216.  

    Study Brochure 


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