• Research in the Department of Transplantation

    There is an active clinical research program in the Department of Transplantation. We are currently involved in 15 industry sponsored clinical trials looking at the effects of various drugs at different stages of development. Many of the studies involve treatment of hepatitis B or C, both before and after liver transplantation. For example, we are studying a drug that keeps platelet counts at a reasonable level during treatment for hepatitis C. Platelets are the blood cells that help blood to clot, and one of the major side effects of treatment for hepatitis C is very low platelet counts. If this drug is able to keep platelets at an acceptable level, it may allow more patients to complete the recommended treatment and clear their blood of the virus. We are also looking at drugs that are used in addition to the standard hepatitis C medications to see if they increase the rate at which patients become virus-free.

    The other major category of clinical trials involves the study of immunosuppressive agents. Some of the studies involve new agents, while others involve using standard immunosuppressive drugs in new combinations.

    Please visit the Research section of Lahey's Web site to view a complete listing of current trials.

    The Department also participates in two federally funded research grants designed to improve outcomes of our transplant patients. The first grant examines outcomes of donors and recipients in our live donor liver population and is called A2ALL (Adult to Adult Living Donor Liver Transplantation Cohort study). It consists of nine transplant centers in the United States and Canada that have agreed to share their data, with the goal of determining the practices that are most beneficial to these patients. More complete information may be found by visiting the A2ALL Web site.

    The second grant is from the National Cancer Institute via the American College of Radiology Imaging Network. Another multi-center study, this research is aimed at defining the criteria for the diagnosis of hepatocellular carcinoma and measuring its response to treatment.

    Members of the Department of Transplantation regularly analyze the outcomes of our transplant program. The results are presented at national and international transplant meetings and are submitted to peer-reviewed journals for publication. View recent publications.

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  • HRSA Award

    Health Resources and Services Administration (HRSA) Awards Lahey Clinic the Silver1 Medal of Honor for Organ Donation.