by Glickman-Simon R

  • Atherosclerosis
  • Coronary Heart Disease

Coronary artery disease (CAD) is the most common form of heart disease. Blood vessels that bring blood to the heart muscle are narrowed. It can slow or stop blood flow to the heart. Blood vessels are narrowed by a process called atherosclerosis. Fat, cholesterol, and calcium stick to blood vessel walls and form a plaque. The plaque can damage the blood vessels walls. This can lead to blood clots. The clots and plaque both make the blood vessel more narrow. It also makes it easier for more plaque to develop. Blocked blood flow in these blood vessels can lead to a heart attack.

Treatment can help to slow or stop buildup of plaque, open narrow arteries, and decrease the risk of clotting. One step is to manage factors that lead to CAD. This includes:

  • Decreasing blood pressure and cholesterol
  • Managing diabetes
  • Losing weight if overweight
  • Quitting smoking

Information on these issues can be found in separate articles. The following include supplements that were specifically studied for impact on CAD.

Natural Therapies

Possibly Effective

Dietary factors that may reduce the risk of CAD:

Therapy that may affect CAD include:

  • Music therapy may reduce anxiety and possibly chest pain in patients with coronary artery disease. C1
  • Yoga may reduce blood pressure. C2

Possibly Not Effective

These supplements may not be effective:

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Herbs and Supplements to Be Used With Caution

Talk to your doctor about any alternative therapy you are taking to make sure it does not interfere with your treatment plan. Some supplement discussed here have certain concerns such as:

  • Vitamin C can reduce the effectiveness of certain medications, such as blood thinners.
  • Vitamin E has a blood-thinning effect that may cause problems in those who also take blood thinners. If you have diabetes or are being treated for cancer, talk to your doctor before you take vitamin E.

References

REFA Dietary changes

REFA1 Ong HT, Cheah JS. Statin alternatives or just placebo: an objective review of omega-3, red yeast rice and garlic in cardiovascular therapeutics. Chinese Medical Journal. 2008;121(16):1588–1594.

REFA2 Reinhart KM, Talati R, et al. The impact of garlic on lipid parameters: a systematic review and meta-analysis. Nutrition Research Reviews. 2009;22(1):39-48.

REFA3 Huang J, Frohlich J, et al. The impact of dietary changes and dietary supplements on lipid profile. Canadian Journal of Cardiology. 2011;27(4):488-505.

REFA4 Freedman ND, Park Y, et al. Association of coffee drinking with total and cause-specific mortality. N Engl J Med. 2012 May 17;366(20):1891-904

REFA5 Stabler SN, Tejani AM, et al. Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients. Cochrane Database of Systematic Reviews. 2012;(8)CD007653.

REFA6 Ding M, Bhupathiraju SN, et al. Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies. Circulation. 2014 Feb 11;129(6):643-59.

REFA7 Zhang C, Qin YY, et al. Tea consumption and risk of cardiovascular outcomes and total mortality: a systematic review and meta-analysis of prospective observational studies. Eur J Epidemiol. 2015 Feb;30(2):103-13.

REFA8 Xiong XJ, Wang PQ, et al. Garlic for hypertension: A systematic review and meta-analysis of randomized controlled trials.Phytomedicine. 2015 Mar 15;22(3):352-61.

REFA9 Kwok CS, Boekholdt SM, et al. Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women. Heart. 2015 Aug;101(16):1279-87.

REFA10 Larsson SC, Åkesson A, et al. Chocolate consumption and risk of myocardial infarction: a prospective study and meta-analysis. Heart. 2016 Jul 1;102(13):1017-22.

Supplements

REFB1 Hooper L, Thompson RL, et al. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD003177.

REFB2 Lee IM, Cook NR, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer. The women’s health study: a randomized controlled trial. The Journal of the American Medical Association. 2005;294(1):56–65.

REFB3 Cook NR, Albert CM, et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med. 2007;167:1610-1618.

REFB4 Ong HT, Cheah JS. Statin alternatives or just placebo: an objective review of omega-3, red yeast rice and garlic in cardiovascular therapeutics. Chin Med J (Engl). 2008;121:1588-1594.

REFB5 Sesso HD, Buring JE, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2008;300:2123-2133.

REFB6 Mei W, Rong Y, et al. Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials. Int J Clin Pract. 2010 Jan;64(2):208-15.

REFB7 Miller ER 3rd, Juraschek S, et al. Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels. Am J Cardiol. 2010 Aug 15;106(4):517-27.

REFB8 Kwak SM, Myung SK, et al. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Arch Intern Med. 2012 Apr 9.

REFB9 Rees K, Hartley L, et al. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013 Jan 31;(1):CD009671.

REFB10 Martí-Carvajal AJ, Solà I, et al. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2015 Jan 15;1:CD006612.

REFB11 Jenkins DJA, Spence JD, et al. Supplemental Vitamins and Minerals for CVD Prevention and Treatment. J Am Coll Cardiol. 2018 Jun 5;71(22):2570-2584.

REFB12 Hooper L, Al-Khudairy L, et al. Omega-6 fats for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018 Jul 18;7:CD011094.

REFC Other therapies

REFC1 Bradt J, Dileo C, et al. Music for stress and anxiety reduction in coronary heart disease patients. Cochrane Database Syst Rev. 2013 Dec 28;(12):CD006577.

REFC2 Hartley L, Dyakova M, et al. Yoga for the primary prevention of cardiovascular diseases. Cochrane Database Syst Rev. 2014;5:CD010072.

Revision Information

  • Reviewer: EBSCO NAT Review Board Richard Glickman-Simon, MD
  • Review Date: 03/2019
  • Update Date: 03/02/2019