Acute tubular necrosis (ATN) is an injury to the tiny tube-shaped cells in the kidneys. ATN can lead to more serious kidney problems.
|Anatomy of the Kidney|
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ATN may be caused by:
Lack of blood flow and oxygen to the kidneys from:
- Blood clots
- Blood loss
- Loss of fluids from dehydration
- Problems from surgery
- Damage to kidney cells from things like medicines, contrast material used in imaging, and certain drugs
Things that may raise the risk of this problem are:
- Taking certain medicines
- Using certain illegal drugs
- Having certain health problems, such as:
- Kidney, heart, liver, or lung disease
- Blood pressure that is too high or low
- Blood loss from surgery
ATN may cause:
- Urinating more or less than normal
- Lack of hunger
- Nausea and vomiting
- Weight gain
The doctor will ask about your symptoms and health history. A physical exam will be done.
Blood and urine tests will be done to look for problems with how the kidneys are working. Other tests will be done to find a cause. You may need to see a doctor who treats kidney diseases.
Care depends on what is causing the problem. Options are:
- Supportive care, such as fluids, nutrition, and oxygen
- Stopping or changing medicines that are harming the kidneys
- Medicines to:
- Control health problems that are causing ATN
- Manage problems caused by ATN, such as swelling, nausea, or feeling tired
- Dialysis to filter blood when the kidneys cannot
National Institute of Diabetes and Digestive and Kidney Diseases https//www.niddk.nih.gov
National Kidney Foundation https://www.kidney.org
Health Canada https://www.canada.ca
The Kidney Foundation of Canada https://www.kidney.ca
Acute tubular necrosis. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/acute-tubular-necrosis. Accessed December 29, 2020.
Acute tubular necrosis (ATN). Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/home/kidney-and-urinary-tract-disorders/kidney-filtering-disorders/acute-tubular-necrosis. Accessed December 29, 2020.
Levey, A , James, M. Acute kidney injury. Ann Intern Med. 2017 Nov 7;167(9):ITC66-ITC80.
- Reviewer: EBSCO Medical Review Board Adrienne Carmack, MD
- Review Date: 09/2020
- Update Date: 12/29/2020