by EBSCO Medical Review Board


Apnea of prematurity is a brief stop in breathing in babies born before 35 weeks of pregnancy. It lasts 15 to 20 seconds. The brief stop may be less than 15 seconds if the baby has a slow heart rate or turns blue or pale.


This problem may be caused by an immature nervous system, weak breathing muscles, or a mix of both.

The brain controls breathing. It should sense the need to breathe and tell the body to do it. Young nervous systems may not be able to do this. This is called central apnea.

Premature babies may also have weak breathing muscles. They cannot support the airway and keep it open. This makes it hard to breathe. This is called obstructive apnea.

Normal Upper Airway During Sleep
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Risk Factors

This problem is more common in babies born before 35 weeks of pregnancy. The risk is greater the earlier a baby is born.

Other things that may raise the risk are:

  • Genetics
  • Cesarean delivery
  • Conception through fertility treatments
  • Lack of red blood cells (anemia)
  • Gastroesophageal reflux


Symptoms happen in the first week of life. They may be:

  • Long pauses between breaths
  • Bluish skin color
  • Slow heart rate


The doctor will ask about your baby's symptoms and health history. A physical will be done. It will focus on your baby's breathing and heart rate.

Blood tests will be done.

Images may be taken of your baby's chest, belly, and head. This can be done with:


Apnea will go away on its own as a baby reaches what would have been the 36th week of pregnancy.

Treatment may be needed to manage symptoms until the apnea goes away. This is often done in the hospital. Choices are:

  • Rubbing or patting the baby to get breathing started again
  • Medicines to help with breathing, such as caffeine
  • Breathing support, such as a continuous positive airway pressure (CPAP) machine to help take over breathing if there is a long pause


There are no known methods to prevent this health problem.


Healthy Children—American Academy of Pediatrics 

Kids Health—Nemours Foundation 


Caring for Kids—Canadian Paediatric Society 

Health Canada 


Apnea of prematurity. EBSCO DynaMed website. Available at: Accessed December 15, 2020.

Apnea of prematurity. Johns Hopkins Medicine website. Available at:,ApneaOfPrematurity. Accessed December 15, 2020.

Apnea of prematurity. Kids Health—Nemours Foundation website. Available at: Accessed December 15, 2020.

Bloch-Salisbury E, Hall MH, et al. Heritability of apnea of prematurity: a retrospective twin study. Pediatrics. 2010 Oct;126(4):e779-787.

Fechner A, Brown K, et al. Effect of single embryo transfer on the risk of preterm birth associated with in vitro fertilization. J Assist Reprod Genet. 2015 Feb;32(2):221-224.

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