Calcium pyrophosphate dihydrate deposition disease (CPPD) is a buildup of calcium crystals in the joints. This results in inflammation in the joints.
|Arthritis of the Knee|
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This problem is more common in people who are over 50 years of age.
Other things that may raise the risk are:
Most people do not have symptoms. Those who do may have pain in the knee, wrist, hand, pelvis, or hip. It may get worse over a 6 to 24 hour span. Symptoms may also flare up and then go away for a time before returning.
Problems may be:
- Joint pain
- Joint stiffness and swelling
- Redness over the joint
The doctor will ask about your symptoms and health history. A physical exam will be done.
Your blood may be tested.
A needle may be used to remove and test a sample of the fluid in a joint. This can be done with a synovial fluid analysis.
Images may be needed. This can be done with:
There is no cure. The goal of treatment is to manage symptoms during flare-ups. Choices are:
- Supportive care, such as cold compresses and resting the joint
- Medicines to ease pain and swelling, such as:
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Gout medicines like colchicine that change the way the body reacts to the crystals
People who are not helped by these methods may need arthrocentesis. It uses a needle to remove excess fluid from a joint.
American College of Rheumatology http://www.rheumatology.org
National Institute of Arthritis and Musculoskeletal and Skin Diseases http://www.niams.nih.gov
The Arthritis Society http://www.arthritis.ca
Health Canada https://www.canada.ca
Calcium pyrophosphate deposition (CPPD). American College of Rheumatology website. Available at: https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Calcium-Pyrophosphate-Deposition-CPPD. Accessed February 16, 2021.
Calcium pyrophosphate dihydrate deposition disease. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/calcium-pyrophosphate-dihydrate-deposition-disease. Accessed February 16, 2021.
Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) (Pseudogout). The Arthritis Foundation website. Available at: http://www.arthritis.org/about-arthritis/types/calcium-pyrophosphate-deposition-disease-cppd. Accessed February 16, 2021.
Calcium pyrophosphate dihydrate deposition disease (CPPD, or Pseudogout). Cleveland Clinic website. Available at: http://my.clevelandclinic.org/services/orthopaedics-rheumatology/diseases-conditions/hic-pseudogout. Accessed February 16, 2021.
Rosenthal AK, Ryan LM. Calcium Pyrophosphate Deposition Disease. N Engl J Med. 2016 Jun 30;374(26):2575-2584.
- Reviewer: EBSCO Medical Review Board Warren A. Bodine, DO, CAQSM
- Review Date: 12/2020
- Update Date: 02/16/2021