by EBSCO Medical Review Board
(Acute Inflammatory Demyelinating Polyradiculoneuropathy; Acute Inflammatory Demyelinating Polyneuropathy; Acute Idiopathic Polyneuritis; Acute Inflammatory Polyneuropathy; Acute Autoimmune Neuropathy; Idiopathic Polyneuritis; AIDP)


Guillain-Barré syndrome is a rare problem that causes the immune system to attack the nerves. This results in muscle weakness.

Nervous System
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The exact cause is not known. In some people, it is triggered by a recent infection.

Risk Factors

Guillain-Barré syndrome is more common in men. The risk gets higher with age. Other things that may raise the risk are:

  • Recent infection
  • Stress-related disorder
  • Recent vaccination (rare)


Problems may happen over hours, days, or weeks. It will get worse over time. Problems may be:

  • Weakness and tingling in the legs, arms, and face
  • Pain in the legs or back
  • Problems walking or climbing stairs
  • Problems breathing
  • Eyesight problems
  • Problems swallowing, speaking, or chewing
  • Problems urinating


The doctor will ask about your symptoms and health history. A physical exam will be done. This is often enough to make the diagnosis. These tests may be done to support it:


The goal is to manage symptoms and help speed healing. Hospital care will be needed to watch for things like breathing and heart problems. Most people get better, but others may have lasting problems.

Treatment choices are:

IV Immunoglobulin Therapy (IVIG)

Immunoglobulins are proteins in the blood that fight infections. IVIG uses an IV to give a person proteins donated from a healthy person.


Plasmapheresis removes blood from the body and passes it through a machine that separates blood cells. The cells are then returned to the body with new plasma. This may help a person get better more quickly.


Physical and occupational therapy may be needed. It can help a person with strength and motion. It can also help a person learn how to do daily tasks again.


There are no guidelines to lower the risk of this health problem.


Guillain-Barré Syndrome Foundation International 

National Institute of Neurological Disorders and Stroke 


Canadian Institute for Health Information 

Health Canada 


Donofrio PD. Guillain-Barré Syndrome. Continuum (Minneap Minn). 2017 Oct;23(5, Peripheral Nerve and Motor Neuron Disorders):1295-1309.

Guillain-Barre syndrome. Centers for Disease Control and Prevention website. Available at: Updated December 20, 2019. Accessed April 13, 2020.

Guillain-Barre syndrome. EBSCO DynaMed website. Available at:  . Updated August 2, 2019. Accessed April 13, 2020.

Guillain-Barre syndrome fact sheet. EBSCO DynaMed website. Available at: Updated March 27, 2019. Accessed April 13, 2020.

Revision Information

  • Reviewer: EBSCO Medical Review Board Rimas Lukas, MD
  • Review Date: 02/2020
  • Update Date: 04/13/2020