Hemophilia is a group of bleeding disorders. Certain blood clotting factors are too low or missing. These help to stop bleeding.
The most common types are:
- Hemophilia A (classic hemophilia)—caused by too little or no factor VIII (most common)
- Hemophilia B (Christmas disease)—happens in males, caused by too little or no factor IX
A faulty gene on a certain DNA strand causes hemophilia. Females carry 2 copies of the strand. If one is faulty, the other one takes over. The faulty gene can pass to their children. If so, the female child will carry the gene. If it passes to the male, they will get the disease because they carry one copy of the strand.
It’s possible for a female to get the disease. They would have to get the faulty gene from both parents.
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Symptoms differ based on severity. Bleeding is the main issue. It’s often related to an injury or surgery. In babies, the disease may not show until they are mobile. Milder versions may not be noticed until later in life.
The most common are:
- Easy bruising
- Repeated nosebleeds
- Blood in the urine
- Blood in the stool
- Heavy bleeding after minor cuts or bumps
- Bleeding after dental work or surgery
- Bleeding in the joints causing pain
- Heavy periods in women who carry the gene
The doctor will ask about your symptoms and health history. Your answers and a physical exam may point to hemophilia. You may also have blood tests to see how well your blood clots. These tests will also look for low or missing clotting factors.
Care may involve:
An injection replaces the missing factor. It’s based on the type of disease you have. You will watch your levels with a test. The dose is used when the levels drop too low. If you have a high risk of bleeding for any reason, you take a dose ahead of time.
This factor can be given at home. You and others will learn how to give it. It’s used at the first signs of bleeding. This can help avert a crisis. People with serious forms sometimes need doses at scheduled times.
Some people may need more than one clotting factor.
Mild hemophilia A is treated with medicine. The medicine causes the release of blood factor. It’s stored within the lining of the blood vessels.
To lower your chances of bleeding:
- Take care of your teeth. It may lower the chances of needing major work.
Take care when involved in activities:
- Protect your head from injuries.
- You may need to avoid contact sports.
Don’t use medicines that can make bleeding worse such as:
- Blood thinners
- Certain pain medicines
American Society of Hematology http://www.hematology.org
National Hemophilia Foundation https://www.hemophilia.org
Canadian Hemophilia Society http://www.hemophilia.ca
Caring for Kids—Canadian Paediatric Society https://www.caringforkids.cps.ca
What is hemophilia? National Heart, Lung, and Blood Institute website. Available at: https://www.nhlbi.nih.gov/health-topics/hemophilia. Accessed July 17, 2018.
Hemophilia A. EBSCO DynaMed Plus website. Available at: https://www.dynamed.com/topics/dmp~AN~T115190/Hemophilia-A . Updated May 19, 2017. Accessed July 17, 2018.
Hemophilia B. EBSCO DynaMed Plus website. Available at: https://www.dynamed.com/topics/dmp~AN~T113770/Hemophilia-B . Updated February 8, 2018. Accessed July 17, 2018.
10/24/2012 DynaMed's Systematic Literature Surveillance. https://www.dynamed.com/topics/dmp~AN~T113770/Hemophilia-B : Broderick CR, Herbert RD, Latimer J, et al. Association between physical activity and risk of bleeding in children with hemophilia. JAMA. 2012;308(14):1452-1459.
- Reviewer: EBSCO Medical Review Board Michael Fucci, DO, FACC
- Review Date: 05/2018
- Update Date: 07/17/2018