Supplement Forms/Alternate Names

  • NADH


Nicotinamide adenine dinucleotide (NADH) is a compound in the body that helps in energy production. It has been used to ease fatigue and improve brain function. NADH can be taken as a pill or powder.


10 to 20 milligrams daily

What Research Shows

May Be Effective

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take nicotinamide adenine dinucleotide in small doses for a short time. Not enough studies have been done to say whether it is safe to use for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.


REFA Chronic Fatigue Syndrome

REFA1 Alegre J, Rosés JM, et al. [Nicotinamide adenine dinucleotide (NADH) in patients with chronic fatigue syndrome]. Rev Clin Esp. 2010;210(6):284-288.

REFA2 Alraek T, Lee MS, et al. Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review. BMC Complement Altern Med. 2011 Oct 7;11:87.

REFA3 Reid S, Chalder T, et al. Chronic fatigue syndrome. BMJ Clin Evid. 2011 May 26;2011. pii: 1101.

REFA4 Castro-Marrero J, Cordero MD, et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? Antioxid Redox Signal. 2015;22(8):679-685.

REFA5 Castro-Marrero J, Sáez-FrancásN, et al. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial. Clin Nutr. 2016;35(4):826-834.

REFA6 Campagnolo N, Johnston S, et al. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review. J Hum Nutr Diet. 2017 Jun;30(3):247-259.

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 03/2020
  • Update Date: 06/29/2020