Peyronie disease is a buildup of scar tissue in the penis. It causes the penis to curve during erections. This causes pain.

It is treated with medicine. Some people may need surgery. Natural therapies have been used to ease pain. They should not be used in place of standard care.

Natural Therapies

May Be Effective

These herbs and supplements may be effective:

  • Antioxidants are substances that may slow damage to cells. A4
  • Coenzyme Q10 is a protein in the body that helps make energy. A2
  • Vitamin E is found in nuts and olive oil. The body uses it as an antioxidant to help slow damage to cells. A3, A5

Not Enough Data to Assess

  • PABA (para-aminobenzoic acid) A1
  • Shock wave therapy B1

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Herbs and Supplements to Be Used With Caution

Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse. For example, PABA (para-aminobenzoic acid) should not be taken by people taking antibiotics, people with ulcerative colitis, or people that are about to have surgery.


Herbs and Supplements

REFA1 Hasche-Klünder R. [Treatment of Peyronie’s disease with para-aminobenzoacidic potassium (POTOBA) (author’s transl)]. Urologgee A. 1978;17(4):224-227.

REFA2 Safarinejad MR. Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie’s disease: a double-blind, placebo-controlled randomized trial. Int J Impot Res. 2010;22(5):298-309.

REFA3 Paulis G, Brancato T, et al. Efficacy of vitamin E in the conservative treatment of Peyronie’s disease: legend or reality? A controlled study of 70 cases. Andrology. 2013;1(1):120-128.

REFA4 Paulis G, Cavallini G, et al. Long-term multimodal therapy (verapamil associated with propolis, blueberry, vitamin E and local diclofenac) on patients with Peyronie's disease (chronic inflammation of the tunica albuginea). Results of a controlled study. Inflamm Allergy Drug Targets. 2013 Dec;12(6):403-409.

REFA5 Prieto Castro RM, Leva Vallejo ME, et al. Combined treatment with vitamin E and colchicine in the early stages of Peyronie's disease. BJU Int. 2003 Apr;91(6):522-524.

Shock wave therapy

REFB1 Hauck EW, Mueller UO, et al. Extracorporeal shock wave therapy for Peyronie’s disease: exploratory meta-analysis of clinical trials. J Urol. 2004;171(2):740-745.

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 05/2019
  • Update Date: 06/12/2020