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by Jones P
(PD; Chronic Inflammation of the Tunica Albuginea; Penile Curvature)

Definition

Peyronie disease (PD) is a growth of scar tissue under the skin of the penis. It causes a bend in the penis.

Causes

The exact cause of PD is not clear. Injury to the area may play a role. A problem with the immune system may play a role for some.

Risk Factors

Things that may increase the risk of PD include:

  • Trauma to penis
  • Others in family have PD
  • Smoking or other tobacco use
  • Frequent alcohol use
  • Surgery in the area such as prostatectomy
  • Diabetes mellitus

Symptoms

Symptoms may develop fast or slow and may include:

  • Hard lumps on penis
  • Bend in penis—may only be apparent during erection
  • Change in penis shape which may include a dent, or change in size
  • Pain during erection
  • Sex is painful or impossible

Pain may decrease over time. Symptoms can lead to problems having sex or erectile dysfunction (ED).

Diagnosis

The doctor will ask about your symptoms and past. A physical exam will be done. PD is often diagnosed based on symptoms and exam.

Treatment

PD does not always need treatment. When needed treatment can help to ease pain and straighten the penis. It may also ease problems with sexual performance. Treatment choices are:

Medicine

  • Pills—may slow growth of scar tissue
  • Injections—may decrease scar tissue and easy curve of penis
  • Gels—applied to penis may reduce curve, scarring, and pain with erection
  • Coenzyme Q10 or Vitamin E plus colchicine—may help ease curve in early stages

Surgery

This may be chosen if other treatments have not helped. It may be done if sex is painful or impossible because of the curve. Surgery may delayed until curve is no longer changing. Choices may include:

  • Remove scar tissue and replace with graft from other area.
  • Pinch or tighten penis on opposite side. It will help to straighten the penis. It may shorten the penis.
  • Implant a device. It can assist an erection or straighten it out.

Prevention

There are no steps to prevent PD.

RESOURCES

Family Doctor—American Academy of Family Physicians  https://familydoctor.org  

Urology Care Foundation  https://www.urologyhealth.org 

CANADIAN RESOURCES

Health Canada  https://www.canada.ca 

Sex & U—The Society of Obstetricians and Gynaecologists of Canada  http://www.sexandu.ca 

References

Penile Curvature (Peyronie Disease). National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: https://www.niddk.nih.gov/health-information/urologic-diseases/penile-curvature-peyronies-disease. Updated August 2019. Accessed November 11. 2019.

Peyronie Disease. EBSCO DynaMed website. Available at:  https://www.dynamed.com/condition/peyronie-disease-14 . Updated April 22, 2019. Accessed November 11. 2019.

Ralph D, Gonzalez-Cadavid N, Mirone V, et al. The management of Peyronie's disease: evidence-based 2010 guidelines. J Sex Med. 2010 Jul;7(7):2359-74

Revision Information

  • Reviewer: EBSCO Medical Review Board
  • Review Date: 12/2019
  • Update Date: 12/20/2019