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by Alan R


Rhabdomyolysis is a group of symptoms. It caused by the breakdown of muscle tissue. Proteins called myoglobin are then released into the blood flow. These proteins can cause severe damage to the kidneys.


The muscle damage may be caused by:

  • Excessive muscle activity
  • Certain muscle diseases
  • Severe muscle injuries such as a crush injury
  • Overuse of alcohol or illicit drugs
  • Uncontrolled seizure disorder
  • Body is too cold— hypothermia
  • Body is too hot— heat stroke
  • Contact with electrical current Electrical burns
  • Poison from a snake or spider bite
  • Major surgical procedures that need large, muscle incisions—rare

Risk Factors

Factors that may increase your chance of muscle damage include:

  • Extreme exertion, such as running a marathon
  • Heat stroke
  • Use of some prescription drugs
  • Alcohol or drug abuse
  • Severe seizures or convulsions


The most common symptoms include:

  • Dark urine—brown or red in color (tea-colored)
  • Muscle pain
  • Muscle weakness

Other symptoms include:

  • Muscle swelling
  • Back pain
  • Nausea or vomiting

In severe cases, rhabdomyolysis may result in:

Anatomy of the Kidney
Copyright © Nucleus Medical Media, Inc.


You will be asked about your symptoms and medical history. A physical exam will be done. The doctor may suspect rhabdo based on symptoms and recent past.

To confirm the diagnosis your may test:

  • Blood—to look for markers of muscle damage
  • Urine—to look for myoglobin, a protein released with muscle damage (only appears in urine if there are high levels in blood)

The activity of your muscles and heart may be tested. This can be done with:

  • Electromyography EMG
  • ECG —heart may be affected by electrolytes changes


Treatment may include:


Large amounts of fluid are the main treatment. The fluids are usually given by IV. This will help to quickly flush the myoglobin out of the kidneys. It can help the kidneys work well again.


Bicarbonate may be used to minimize myoglobin's toxic effects.


Dialysis is a procedure that uses a machine to filter blood when the kidneys are not functioning. The clean blood is then returned to your body.


To reduce your chance of muscle damage and rhabdomyolysis:

  • Drink plenty of fluids when:
    • Exercising
    • Sitting or working in hot weather
  • Drink alcohol in moderation—this is 2 drinks per day for men and 1 drink per day for women
  • Avoid illicit drugs


Family Doctor—American Academy of Family Physicians  https://familydoctor.org 

National Kidney Foundation  https://www.kidney.org 


Health Canada  https://www.canada.ca 

The Kidney Foundation of Canada  https://www.kidney.ca 


Rhabdomyolysis. EBSCO DynaMed Plus website. Available at:  https://www.dynamed.com/topics/dmp~AN~T114269/Rhabdomyolysis  . Updated August 31, 2016. Accessed June 13, 2018.

Sauret JM, Marinides G, Wang GK. Rhabdomyolysis. Am Fam Physician. 2002:65(5):907-913.

Torres PA, Helmstetter JA, Kaye AM, Kaye AD. Rhabdomyolysis: Pathogenesis, diagnosis, and treatment. Ochsner J. 2015;15(1):58-69.

Revision Information

  • Reviewer: EBSCO Medical Review Board Adrienne Carmack, MD
  • Review Date: 05/2018
  • Update Date: 06/13/2018