Silica hydride is a mineral. It has been used as an antioxidant to help slow damage to cells. Silica hydride has not yet been tested on humans or animals. It can be taken as a pill or powder, but it is not widely available.


There are no advised doses for silica hydride.

What Research Shows

There is not enough data to support that silica hydride is helpful in treating health problems. We will review future studies as they are published.

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

Not enough studies have been done to say whether it is safe to take silica hydride.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.


REF1 Stephanson CJ, Flanagan GP. Differential metabolic effects on mitochondria by silica hydride using capillary electrophoresis. J Med Food. 2004;7:79-83.

REF2 Stephanson CJ, Stephanson AM, Flanagan GP. Evaluation of hydroxyl radical-scavenging abilities of silica hydride, an antioxidant compound, by a Fe2+-EDTA-induced 2-hydroxyterephthalate fluorometric analysis. J Med Food. 2003;6:249-53.

REF3 Stephanson CJ, Flanagan GP. Antioxidant capacity of silica hydride: a combinational photosensitization and fluorescence detection assay. Free Radic Biol Med. 2003;35:1129-1137.

REF4 Stephanson CJ, Stephanson AM, Flanagan GP. Antioxidant capability and efficacy of Mega-H silica hydride, an antioxidant dietary supplement, by in vitro cellular analysis using photosensitization and fluorescence detection. J Med Food. 2002;5:9-16.

REF5 Glazier LR, Stellingwerff T, Spriet LL. Effects of microhydrin supplementation on endurance performance and metabolism in well-trained cyclists. Int J Sport Nutr Exerc Metab. 2004;14:560-573.

REF6 Mega H-Hydrogen (H-): the fuel of life. VitaNet website. Available at: Accessed 6/24/07

REF7 Purdy-Lloyd K, Wasmund W, Smith L, et al. Clinical effects of a dietary antioxidant silicate supplement, microhydrin, on cardiovascular response to exercise. J Med Food. 2001:151-159.

REF8 Lloyd K, Howard, Clinton. Abstracts of evaluation studies of microhydrin, a functional silicate nanocolloid. Royal Health website. Available at: Accessed 6/25/07

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 07/2019
  • Update Date: 03/27/2020