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(SSPE; Dawson Disease)

Definition

Subacute sclerosing panencephalitis (SSPE) is a rare and deadly brain disorder. It causes problems with thinking, uncontrolled movements, and seizures that worsen over time.

Central Nervous System
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Causes

SSPE is caused by an altered form of the measles virus. It occurs 7 to 10 years after a person has the measles.

Risk Factors

The risk is higher in people who get measles before they are 2 years of age. SSPE usually starts in children or young adults. It is also more common in males and people who were not vaccinated against measles.

Symptoms

Problems worsen over time. A person may have:

  • Changes in behavior
  • Problems learning
  • Outbursts
  • Memory loss
  • Lack of focus
  • Being very tired
  • Jerking muscles
  • Seeing things that are not there
  • Problems speaking
  • Problems swallowing
  • Blindness
  • Seizures

Diagnosis

The doctor will ask about your symptoms and health history, including whether you have had measles. A physical exam will be done. This may be enough to suspect SSPE.

Blood tests may be done. A lumbar puncture may also be done to test the fluid around the brain and spine.

An electrocardiogram (EKG) may be done to look at how the heart is working.

Images of the brain will be taken. This can be done with:

Treatment

There is no cure. Supportive care will be needed as the disease worsens. Medicine may also be given to help control seizures.

Prevention

The best way to prevent SSPE is to get vaccinated to prevent getting measles.

RESOURCES

Centers for Disease Control and Prevention  http://www.cdc.gov 

National Institute of Neurological Disorders and Stroke  https://www.ninds.nih.gov 

CANADIAN RESOURCES

Canadian Neurological Sciences Federation  http://www.cnsfederation.org 

Public Health Agency of Canada  http://www.phac-aspc.gc.ca 

References

Chiu MH, Meatherall B, Nikolic A, et al. Lancet Infect Dis. 2016 Jan [Epub ahead of print].

Complications of measles. Center for Disease Control (CDC) website. Available at: http://www.cdc.gov/measles/about/complications.html. Updated June 13, 2019. Accessed April 14, 2020.

Measles. EBSCO DynaMed website. Available at:  https://www.dynamed.com/condition/measles  . Updated March 5, 2020. Accessed April 14, 2020.

Rota PA, Moss WJ, Takeda M, et al. Measles. Nat Rev Dis Primers. 2016;2:16049.

Subacute sclerosing panencephalitis information page. National Institute of Neurological Disorders and Stroke website. Available at: https://www.ninds.nih.gov/Disorders/All-Disorders/Subacute-Sclerosing-Panencephalitis-Information-Page. March 27, 2019. Accessed April 14, 2020.

Subacute sclerosing panencephalitis (SSPE). Merck Manual Professional Version website. Available at: https://www.ninds.nih.gov/Disorders/All-Disorders/Subacute-Sclerosing-Panencephalitis-Information-Page. Updated August 2019. Accessed April 14, 2020.

Revision Information

  • Reviewer: EBSCO Medical Review Board Rimas Lukas, MD
  • Review Date: 02/2020
  • Update Date: 04/14/2020