Supplement Forms/Alternate Names

  • Riboflavin, riboflavin-5-phosphate


Vitamin B2 is found in nuts, leafy greens, and yeast. The body uses vitamin B2 to create energy. Vitamin B2 has been used to improve migraine pain and athletic performance. It is also used to manage vitamin B12 deficiency. It can be taken as a pill or powder.


1.1 milligrams per day for women and 1.3 milligrams per day for men

What Research Shows

May Be Effective

Not Enough Data to Assess

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take vitamin B2 in small doses for a short time. Not enough studies have been done to say whether it is safe to take for a long period. Women who are pregnant or breastfeeding should not take large doses of vitamin B2.


Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.


REFA High Blood Pressure

REFA1 Wilson CP, Ward M, et al. Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up. Am J Clin Nutr. 2012 Mar;95(3):766-772.

REFA2 Wilson CP, McNulty H, et al. Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial. Hypertension. 2013;61(6):1302-1308.

REFB Keratoconus

REFB1 Caporossi A, Mazzotta C, et al. Riboflavin -UVA-induced corneal collagen cross-linking in pediatric patients. Cornea. 2012;31(3):227-231.

REFC Migraine

REFC1 Namazi N, Heshmati J, et al. Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review. Int J Vitam Nutr Res. 2015;85(1-2):79-87.

REFC2 Gaul C, Diener HC, et al. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. J Headache Pain. 2015;16:516.

REFC3 Thompson DF, Saluja HS. Prophylaxis of migraine headaches with riboflavin: A systematic review. J Clin Pharm Ther. 2017 Aug;42(4):394-403.

REFD Multiple Sclerosis

REFD1 Naghashpour M, Majdinasab N, et al. Riboflavin supplementation to patients with multiple sclerosis does not improve disability status nor is riboflavin supplementation correlated to homocysteine. Int J Vitam Nutr Res. 2013;83(5):281-290.

Revision Information

  • Reviewer: EBSCO NAT Review Board Eric Hurwitz, DC
  • Review Date: 07/2019
  • Update Date: 03/26/2020