by Rosenblum L
(Intestinal Lipodystrophy)


Whipple’s disease is a rare infectious disease.


Whipple’s disease is caused by a specific type of bacteria. It causes abnormal changes on the wall of the small intestine. These changes disrupt the villi. Villi are tiny, finger-like structures that stick out from the wall of the intestine to help absorb nutrients. As a result, some nutrients are not absorbed properly and do not reach the rest of the body.

Cross Section of Intestine with Villi
Intestine Cross section
Copyright © Nucleus Medical Media, Inc.

Risk Factors

There is no evidence that Whipple’s disease is passed from person to person. But, there is some evidence that the bacteria may be present in people who are healthy. This suggests that the few people who develop the disease may have an abnormal response to the bacteria. Some people with Whipple’s disease may have a genetic defect that makes them more likely to develop the disease. Whipple’s disease occurs mainly in middle-aged men.


This disease can affect many parts of the body. The small intestine is the main organ affected. Symptoms usually begin slowly and occur in stages. The first stage includes:

  • Pain in the joints (in 90% of cases)
  • Fever

The disease is usually not diagnosed until several years later when additional symptoms may develop. These include:

  • Pain and bloating in the abdomen
  • Diarrhea
  • Fatty, foul-smelling stools
  • Bleeding from the intestines
  • Weight loss
  • Weakness
  • Fatigue (often from anemia )
  • Cough and chest pain
  • Increased skin pigmentation (in 50% of cases)
  • Swollen lymph glands

If the disease is not treated, this second stage may last for a number of years. Then, more severe symptoms may occur due to the lack of nutrients reaching different parts of the body. Symptoms may occur in any part of the body, but most likely the heart, nervous system, brain, lungs, eyes, or skin. If the disease still is not treated, it usually causes death in this third stage.


The doctor will ask about your symptoms and medical history. A physical exam will be done. Tests may include:

  • Blood tests
  • Stool tests
  • Polymerase chain reaction (PCR) test
  • Biopsy
  • CT scan


Taking antibiotics can cure Whipple's disease. Often, a combination of antibiotics is used. Your doctor will work with you to find the best types and doses for you.

Severe Whipple’s disease may require IV antibiotics, fluids, and electrolyte replacement when treatment begins. Electrolytes are salts and other substances in body fluid that the heart and brain need to work properly. Supplements of certain vitamins and minerals that the body is not absorbing normally may be needed. These may include:

  • Iron
  • Folate
  • Vitamins A, B12, D, E, and K
  • Calcium
  • Magnesium

Symptoms usually go away after a few weeks to a few months on antibiotics. Your doctor may check your progress with the PCR test to see if any of the disease-causing bacteria are left. However, you will still need to take antibiotics for 1-2 years to prevent the disease from returning.


There are no current guidelines to prevent Whipple's disease because the cause is unknown.


National Institute of Diabetes and Digestive and Kidney Diseases 

NORD—National Organization for Rare Disorders 


Canadian Association of Gastroenterology 

Health Canada 


Desnues B, Al Moussawi K, Fenollar F. New insights into Whipple's disease and Tropheryma whipplei infections. Microbes Infect. 2010;12(14-15):1102-1110.

Fenollar F, Nicoli F, Paquet C, et al. Progressive dementia associated with ataxia or obesity in patients with Tropheryma whipplei encephalitis. BMC Infect Dis. 2011;11:171.

Fenollar F, Trani M, Davoust B, et al. Prevalence of asymptomatic Tropheryma whipplei carriage among humans and nonhuman primates. J Infect Dis. 2008;197(6):880-887.

Whipple disease. EBSCO DynaMed Plus website. Available at:  . Updated January 19, 2017. Accessed April 4, 2018.

Whipple's disease. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: Updated August 2014. Accessed April 4, 2018.

Revision Information

  • Reviewer: EBSCO Medical Review Board Daus Mahnke, MD
  • Review Date: 03/2018
  • Update Date: 00/93/2013