by Polsdorfer R

Here are the basics about each of the medicines below. Only common problems with them are listed.

Medicines for ADHD can help control hyperactive and impulsive behavior. They may also increase attention span. Some may cause tics as a side effect. This is when a person has movements that they cannot control.

Prescription Medications

Stimulants

Common names are:

  • Methylphenidate
  • Dextroamphetamine
  • Amphetamine
  • Methylphenidate patch
  • Lisdexamfetamine
  • Dexmethylphenidate

Stimulants are the most common treatment for ADHD. They work by changing the action of a brain chemical called dopamine. It can stimulate parts of the brain that are less active. This creates a calming effect that makes it easier to focus. There is a risk these medicines can become addictive. The lowest dose will be given at first. The person will be monitored for changes.

Problems may be:

  • Insomnia
  • Upset stomach
  • Headache
  • Lack of hunger
  • Irritability
  • Rage
  • Confusion
  • Shakiness
  • Seeing or hearing things that are not there
  • Seizures
  • Slowed growth
Antidepressants

There are many types of antidepressants.

Common names are:

  • Bupropion
  • Fluoxetine
  • Sertraline
  • Doxepin
  • Protriptyline
  • Amitriptyline
  • Imipramine
  • Desipramine

These medicines affect two brain chemicals called norepinephrine or serotonin. Most affect both chemicals. Some may only act on one. All are used to treat depression.

Problems may be:

  • Dry mouth
  • Lightheadedness
  • Tiredness
  • Insomnia
  • Sweating
  • Nausea
  • Weight gain
  • Constipation
  • Problems passing urine
  • Blurred vision

Problems with bupropion may be:

  • Weight loss
  • Anxiety
  • Seizures
  • Dry mouth
  • Insomnia
Antipsychotics

Antipsychotics may be given to people who have aggressive behavior.

Common names are:

  • Risperidone
  • Quetiapine

Problems may be:

  • Tiredness
  • Constipation
  • Problems passing urine
  • Dry mouth
  • Blurred vision
  • Muscle spasms
  • Restlessness
  • Abnormal heartbeat
  • Weight gain
Atomoxetine

Atomoxetine is not a stimulant. It works by changing how a brain chemical called norepinephrine works.

Problems may be:

  • Lack of hunger
  • Nausea
  • Vomiting
  • Tiredness
  • Weight loss
  • Slowed growth rate
  • Rapid heartbeat
Modafinil

Modafinil is a drug used to improve wakefulness. It may be helpful in people with ADHD.

Problems may be:

  • Insomnia
  • Belly pain
  • Lack of hunger
  • Cough
  • Fever
  • Runny nose
  • Headache
Clonidine

Clonidine stimulates certain areas of the brain. It works like stimulants. Taking it in the morning increases calming. It can be taken as a pill or used as a patch on the skin.

Problems may be:

  • Dry mouth
  • Sleepiness
  • Lightheadedness
  • Constipation
  • Stomach upset
Guanfacine

Guanfacine helps with impulse and attention problems. It may take two weeks to see results.

It may take 2 weeks before results can be seen. Never take guanfacine with other medicines that have the same drugs.

Problems may be:

  • Headache
  • Lightheadedness
  • Sleepiness,
  • Blurred vision
  • Problems with focus
  • Constipation
  • Dry mouth

References

About ADHD—overview. Children and Adults with Attention-Deficit/Hyperactivity Disorder website. Available at: https://chadd.org/about-adhd/overview. Accessed May 11, 2022.

ADHD. Kids Health—Nemours Foundation website. Available at: https://kidshealth.org/en/parents/adhd.html. Accessed May 11, 2022.

Attention-deficit hyperactivity disorder (ADHD). Family Doctor—American Academy of Family Physicians website. Available at: https://familydoctor.org/condition/attention-deficit-hyperactivity-disorder-adhd. Accessed May 11, 2022.

Attention-deficit/hyperactivity disorder (ADHD). National Institute of Mental Health website. Available at: https://www.nimh.nih.gov/health/topics/attention-deficit-hyperactivity-disorder-adhd. Accessed May 11, 2022.

Attention-deficit hyperactivity disorder (ADHD) in children and adolescents. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/attention-deficit-hyperactivity-disorder-adhd-in-children-and-adolescents. Accessed May 11, 2022.

Understanding ADHD: information for parents. Healthy Children—American Academy of Pediatrics website. Available at: https://www.healthychildren.org/English/health-issues/conditions/adhd/Pages/Understanding-ADHD.aspx. Accessed May 11, 2022.

Revision Information

  • Reviewer: EBSCO Medical Review Board Kari Kuenn, MD
  • Review Date: 11/2021
  • Update Date: 05/13/2022