by EBSCO Medical Review Board

Asthma Management: Quick-Relief and Controller Medications

Here are the basics about each of the medicines below. Only common problems with them are listed.

Prescription Medicine

Short-acting rescue medicine

  • Short acting beta-2-agonists
  • Anticholinergics such as ipratropium bromide
  • Corticosteroids
  • Magnesium sulfate

Long-term control medicines

  • Inhaled corticosteroids
  • Mast cell stabilizers
  • Long-acting beta-2-antagonists
  • Leukotriene modifiers
  • Methylxanthines
  • Immunomodulators
  • Combination agents
Short-acting Rescue Medicines

These drugs can be used to treat sudden symptoms or for long-term control.

Beta-2-agonists (Inhalers)
Asthma Inhaler for a Child
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Common names are:

  • Albuterol
  • Levalbuterol
  • Pirbuterol

These drugs help to open the airways. This can provide quick relief. They can also be used before exercise.

Some problems are:

  • Fast heartbeat
  • Headache
  • Nervousness
  • Tremor
Ipratropium Bromide

Ipratropium opens the airways and may ease mucus. It is inhaled to ease coughing, wheezing, and problems breathing. They are not often used in children.

Ipratropium is often used with other bronchodilators to treat sudden, severe attacks.

Common problems are:

  • Cough
  • Dry mouth
Corticosteroids (Oral)

Common names are:

  • Methylprednisolone
  • Prednisolone
  • Prednisone

These drugs help ease inflammation. They also prevent symptoms from getting worse. They can cause side effects when taken by mouth instead of being inhaled. Long-term use is not advised.

Some problems are:

  • Belly discomfort, nausea, and possibly bleeding in the stomach
  • Lowered resistance to infections
  • Growth suppression (in children)
  • Obesity
  • Diabetes
  • High blood pressure
  • Osteoporosis (thinning of the bones)
  • Cataracts
  • Adrenal suppression
  • Muscle weakness
Magnesium sulfate (inhaled)

Magnesium sulfate may help treat adults with acute asthma.

Long-term Control Medications

These drugs are used to control symptoms and ease inflammation.

Corticosteroids (Inhaler)

Common names are:

  • Beclomethasone
  • Budesonide
  • Flunisolide
  • Fluticasone
  • Mometasone

These drugs reduce, control, and reverse inflammation. They may reduce the need to use corticosteroid pills and rescue medicine as often.

Some problems are:

  • Oral thrush
  • Cough
Mast-cell Stabilizer Inhalers

Common names are:

  • Cromolyn sodium
  • Nedocromil

These drugs may be used to prevent symptoms over the long term. They ease inflammation. They can also be used before exercise.

Some people may have problems with cough when using these.

Long-acting Beta-2-agonists

Common names are:

  • Salmeterol
  • Formoterol

These drugs may be used to prevent symptoms over the long term. They are helpful at night. They are often used with other medicines, such as inhalers. They can also be used before exercise or exposure to an allergen. They should not be used during a sudden attack.

Some problems are:

  • Fast heartbeat
  • Tremor
  • Problems sleeping
  • Nervousness

Long-acting inhalers, like salmeterol can have serious risks. This often happens when they are taken in error and used as rescue inhalers. These drugs are almost always given with an inhaled corticosteroid.

Methylxanthines

Common names include theophylline.

These drugs may be used to prevent symptoms over the long term. They are helpful at night. They open airways and relax muscles around bronchial tubes. They make it easier to clear mucus out of the airway. These are not as often as other drugs. Drug levels need to be closely watched.

Some problems are:

  • Headache
  • Fast heartbeat
  • Problems urinating (peeing)
  • Nervousness
  • Problems sleeping
  • Upset stomach
Leukotriene Modifiers
  • Zafirlukast
  • Montelukast
  • Zileuton

Leukotriene modifiers ease inflammation. These medicines are not used to ease sudden symptoms. They can be used to prevent symptoms.

Some problems are:

  • Flu-like symptoms
  • Nervousness
  • Headache
  • Belly pain
  • Cough

Leukotriene blockers also ease inflammation. They are used for long-term control and prevention in mild asthma.

Some problems are:

  • High liver enzymes
  • Can cause problems when taken with other drugs
Immunomodulators

Omalizumab is a common name for this drug.

This drug is given by injection. It provides long-term control and prevention of symptoms in mild asthma.

Some problems may be:

  • Pain and bruising at the injection site
  • Severe allergic reaction in some people

Some drugs are combined. This make them easier to take. It can prevent people from using the wrong inhaler.

Common combinations are:

  • Fluticasone and salmeterol
  • Budesonide and formoterol

These drugs provide long-term control and prevention of symptoms. They combine a long-acting beta-2-agonist and an inhaled steroid.

The side effects are the same as for each drug.

Triple Combination Therapy

Other medicines may be added to help uncontrolled asthma. They may be added as a separate inhaler. Or, they may be combined in a triple therapy inhaler. They may include:

  • ICS-LABA and LAMA (tiotropium)
  • Fluticasone/umeclidinium/vilanterol

Special Considerations

When taking medicine:

  • Take your medicine as advised. Do not change the amount or schedule.
  • Be aware of the side effects. Tell your doctor if you have any.
  • Talk to your doctor before you stop taking any prescription medicine.
  • Do not share your prescription medicine.
  • Medicines can be harmful when mixed. Talk to your doctor or pharmacist if you are taking more than one, including over-the-counter products and supplements.
  • Plan for refills.

References

Acute asthma exacerbation in children. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/acute-asthma-exacerbation-in-children. Accessed May 9, 2022.

Asthma exacerbation in adults and adolescents. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/asthma-exacerbation-in-adults-and-adolescents. Accessed May 9, 2022.

Asthma in adults and adolescents. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/asthma-in-adults-and-adolescents. Accessed May 9, 2022.

Asthma treatment. Asthma and Allergy Foundation of America website. Available at: https://www.aafa.org/asthma-treatment. Accessed May 9, 2022.

Chronic asthma in children. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/chronic-asthma-in-children. Accessed May 9, 2022.

2022 Global Initiative for Asthma (GINA) global strategy for asthma management and prevention. Available at: https://ginasthma.org/reports. Accessed May 9, 2022.

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