Here are the basics about each of the medicines below. Only common problems with them are listed.
People who have peptic ulcer disease caused by H. pylori infection may need more than 1 medicine.
Prescription Medicines
- Tetracycline
- Metronidazole
- Amoxicillin
- Clarithromycin
- Levaquin
- Cimetidine
- Famotidine
- Nizatidine
- Omeprazole
- Lansoprazole
- Pantoprazole
- Rabeprazole
- Esomeprazole
Prescription Medicines
Common names are:
- Tetracycline
- Metronidazole
- Amoxicillin
- Clarithromycin
- Levofloxacin
Antibiotics can clear the bacterial infection.
Problems may be allergic reactions, such as:
- A new skin rash
- Puffiness of the face or around the eyes
- Problems breathing
Common names are:
- Cimetidine
- Famotidine
- Nizatidine
H-2 blockers help decrease stomach acids. They may be given to help with heartburn and indigestion. Some of these drugs have potential drug interactions with other medicines, so consult your doctor and pharmacist.
Problems may be:
- Light-headedness
- Confusion
- Headache
- Diarrhea
Common names are:
- Omeprazole
- Lansoprazole
- Pantoprazole
- Rabeprazole
- Esomeprazole
Proton pump inhibitors decrease stomach acid. They may be given to help with heartburn, indigestion, and problems swallowing.
Problems may be:
- Light-headedness
- Headache
- Diarrhea
- An increased risk of fractures when taken in high doses or for longer than a year
- Carafate
Sucralfate coats the stomach and the ulcer. It helps protect it from more damage from stomach acid. This can help speed healing.
- Cytotec
Misoprostol protects the stomach lining and decreases acid production. This helps peptic ulcers heal more quickly.
Misoprostol should not be taken by women who are pregnant. It can cause a miscarriage.
Problems may be:
- Nausea
- Stomach cramps
- Diarrhea
Over-the-Counter Medicines
Common names are:
- Gaviscon
- Di-Gel
- Mylanta
- Maalox Advanced Regular Strength
- Tums
Antacids work to lower stomach acid. They can help treat heartburn and indigestion.
Problems may be:
- Diarrhea
- Constipation
Stop Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Nonsteroidal anti-inflammatory drugs (NSAIDs) will need to be stopped during treatment. These can raise the risk of ulcers and slow healing.
References
Lanas A, Chan FKL. Peptic ulcer disease. Lancet. 2017;390(10094):613-624.
Peptic ulcer disease. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/peptic-ulcer-disease. Accessed May 5, 2022.
Peptic ulcer disease. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/gastrointestinal-disorders/gastritis-and-peptic-ulcer-disease/peptic-ulcer-disease. Accessed May 5, 2022.
Peptic ulcers (stomach ulcers). National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: https://www.niddk.nih.gov/health-information/digestive-diseases/peptic-ulcers-stomach-ulcers/all-content. Accessed May 5, 2022.
Revision Information
- Reviewer: EBSCO Medical Review Board Daniel A. Ostrovsky, MD
- Update Date: 05/04/2022