Hydralazine causes dilation of the walls of blood vessels and is sometimes used to treat hypertension.
Hydralazine is known to deplete the blood of vitamin B 6 . Taking B 6 supplements may prevent or reverse side effects of the medication. 1,2
There is some evidence that hydralazine might impair the body's ability to manufacture the substance coenzyme Q 10 (CoQ 10 ). 3 This suggests (but definitely does not prove) that taking CoQ 10 supplements may produce a beneficial effect.
The herb Coleus forskohlii relaxes blood vessels and might have unpredictable effects if combined with hydralazine.
References
REF1 Shils M, et al. (eds.). Modern nutrition in health and disease, 9th ed. Baltimore: Williams and Wilkins, 1999: 1634.
REF2 Goodman L and Gilman A. The pharmacological basis of therapeutics, 9th ed. Hardman J, et al (eds.). New York: McGraw-Hill, 1996: 1562.
REF3 Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q 10 -enzymes by clinically used anti-hypertensive drugs. Res Commun ChemPathol Pharmacol 12(3): 533–40, 1975.