Introduction
Oxerutins are a group of compounds that are taken from plants and fungus. They have been used to improve blood flow and vein function to ease swelling. Oxerutins can be taken as a pill or powder.
Dosages
1 to 2 grams daily
What Research Shows
May Be Effective
- Chronic venous Insufficiency —may ease symptoms A1-A5
May Not Be Effective
- Post-thrombotic syndrome—may not provide benefit C1
Not Enough Data to Assess
- Lymphedema B1
- Pregnancy Support D1
- Venous leg ulcers E1
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Safety Notes
It is likely safe to take oxerutins in small doses for a short time. Not enough studies have been done to say whether they are safe to use for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.
References
REFA Chronic venous insufficiency
REFA1 Petruzzellis V, Troccoli T, et al. Oxerutins (Venoruton): efficacy in chronic venous insufficiency—a double-blind, randomized, controlled study. Angiology. 2002;53(3):257-263.
REFA2 Cesarone MR, Belcaro G, et al. Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency. Angiology. 2006;57(2):131-138.
REFA3 Akbulut B. Calcium dobesilate and oxerutin: effectiveness of combination therapy. Phlebology. 2010 Apr;25(2):66-71.
REFA4 Aziz Z, Tang WL, et al. A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin Pharm Ther. 2015 Apr;40(2):177-185.
REFA5 Martinez-Zapata MJ, Vernooij RW, et al. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2016 Apr 6;4:CD003229.
REFB Lymphoedema
REFB1 Badger C, Preston N, et al. Benzo-pyrones for reducing and controlling lymphoedema of the limbs. Cochrane Database Syst Rev. 2004;(2):CD003140.
REFC Post-Thrombotic Syndrome
REFC1 Morling JR, Broderick C, et al. Rutosides for treatment of post-thrombotic syndrome. Cochrane Database Syst Rev. 2018 Nov 8;11:CD005625.
REFD Pregnancy Support
REFD1 Smyth RM, Aflaifel N, et al. Interventions for varicose veins and leg oedema in pregnancy. Cochrane Database Syst Rev. 2015 Oct 19;(10):CD001066.
REFE Venous Leg Ulcers
REFE1 Scallon C, Bell-Syer SE, et al. Flavonoids for treating venous leg ulcers. Cochrane Database Syst Rev. 2013 May 31;(5):CD006477.