Supplement Forms/Alternate Names
- Diosmetin
- Diosmin
- Hesperidin
- Naringin
- Narirutin
- Neohesperidin
- Nobiletin
- Rutin
- Tangeretin
- Bioflavonoid
Introduction
Citrus bioflavonoids are compounds found in citrus fruits like tangerines, oranges, and grapefruit. They come in combinations or can be taken individually. Citrus bioflavonoids have been used to improve blood flow and ease swelling in the body. They can be taken as a pill or powder. Citrus bioflavonoids can also be applied to the skin as a cream. They have been used to fight signs of aging.
Dosages
500 milligrams 1 to 2 time daily
What Research Shows
May Be Effective
May Not Be Effective
- High cholesterol —may not lower cholesterol levels in men H1
Unlikely to Be Effective
- Lipid profile and High blood pressure—unlikely to lower D1, D2
Not Enough Data to Assess
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.
Safety Notes
It is likely safe to use citrus bioflavonoids on the skin and to take them orally in small doses for a short time. Not enough studies have been done to say whether it is safe to use for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.
Interactions
Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.
References
REFA Hemorrhoid
REFA1 Giannini I, Amato A, et al. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloprotocol. 2015;19(6):339-345.
REFB Diabetes
REFB1 Homayouni F, Haidari F, et al. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled trial. Phytother Res. 2018;32(6):1073-1079.
REFC Radicular Pain
REFC1 Wang Y, Fang W, et al. A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain. Biomed Res Int. 2017;6875968.
REFD Lipid Profile and Blood Pressure
REFD1 Mohammadi M, Ramezani-Jolfaie N, et al. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials. Phytother Res. 2019 Mar;33(3):534-545.
REFD2 acchio A, Prencipe R, et al. Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren®) in addition to complex decongestive therapy on management of breast cancer-related lymphedema. Support Care Cancer. 2019 Apr;27(4):1471-1480.
REFE Bone Loss in Postmenopausal Women
REFE1 Martin BR, McCabe GP, et al. Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women. J Clin Endocrinol Metab. 2016 Mar;101(3):923-927.
REFF Diabetic Cystoid Macular Edema Without Macular Thickening
REFF1 Forte R, Cennamo G, et al. Long-term follow-up of oral administration of flavonoids, Centella asiatica and Melilotus, for diabetic cystoid macular edema without macular thickening. J Ocul Pharmacol Ther. 2013 Oct;29(8):733-737.
REFG Senile Purpura
REFG1 Berlin JM, Eisenberg DP, et al. A randomized, placebo-controlled, double-blind study to evaluate the efficacy of a citrus bioflavanoid blend in the treatment of senile purpura. J Drugs Dermatol. 2011 Jul;10(7):718-722.
REFH High Cholesterol
REFH1 Demonty I, Lin Y, et al. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. J Nutr. 2010 Sep;140(9):1615-1620.